In the cell, many different proteins interact with a specific sets of proteins to onstitute a complicated network. The network regulates the state of the cell in response to stimuli rom outside, signaling cell division, differentiation, production of hormone molecules, and so on. Many diseases including cancer are caused by some malfunction of the network. It is important to reconstitute the network within computers for the simulations of cellular responses to stimuli. The high-throughput and efficient methodologies for protein roduction are contributing to the analyses of the roles of each proteins.
Typical proteis are constituted of several hundred amino acid residues, and the number of possible amino acid sequences is virtually infinite. Thus, most of the possible sequences have not been used by any organism during the four billion year history of life on the earth. We believe that it is possible, by using the cell-free technology, to seek out new functions of proteins and other biomolecules that life on the earth has never reached before.
Division of Cell-Free Sciences
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